Histopathologic findings in congenital grouped pigmentation of the retina.
作者信息
Regillo C D, Eagle R C, Shields J A, Shields C L, Arbizo V V
机构信息
Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107.
出版信息
Ophthalmology. 1993 Mar;100(3):400-5. doi: 10.1016/s0161-6420(93)31635-0.
BACKGROUND
Congenital grouped pigmentation of the retina is a condition characterized by multiple, well-circumscribed, flat, pigmented fundus lesions clustered in a fashion resembling "bear tracks."
METHODS
Light and electron microscopy was used to study these lesions in an eye of a 2-year-old boy. The eye was enucleated for retinoblastoma.
RESULTS
Similar to the classic, solitary, congenital hypertrophy of the retinal pigment epithelium (CHRPE), the involved RPE cells contained an increased number of large pigment granules. Unlike CHRPE, most pigment granules retained the normal ellipsoidal shape. In addition, hypertrophy and hyperplasia of the RPE cells were not significant features by light and electron microscopy.
CONCLUSION
Although the lesions in this case superficially resembled CHRPE by light microscopy, ultrastructural differences were identified.
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