Van Scoy R E, Cohen S N, Geraci J E, Washington J A
Mayo Clin Proc. 1977 Apr;52(4):216-9.
Three patients who had coryneform bacterial endocarditis affecting a prosthetic valve are presented and 64 case reports are reviewed. Diagnostic difficulties occur because coryneform bacteria often are fastidiuos, with long incubation periods, and often contaminate blood cultures. Although some coryneform bacteria are killed by penicillin G, many are resistant to most of the commonly used antibiotics. Vancomycin is bactericidal in resistant strains studied. Treatment with vancomycin is indicated until in vitro bactericidal data are available. Coryneform endocarditis often occurs on prosthetic valves, thus making therapy and its evaluation even more difficult.
本文报告了3例患有棒状杆菌性心内膜炎并累及人工瓣膜的患者，并对64例病例报告进行了回顾。诊断存在困难，因为棒状杆菌通常生长缓慢，潜伏期长，且常污染血培养。虽然一些棒状杆菌可被青霉素G杀灭，但许多对大多数常用抗生素耐药。在所研究的耐药菌株中，万古霉素具有杀菌作用。在获得体外杀菌数据之前，建议使用万古霉素进行治疗。棒状杆菌性心内膜炎常发生在人工瓣膜上，因此使治疗及其评估更加困难。
