Bourke E, Yanagawa N
Department of Medicine, Veterans Administration Medical Center, Brooklyn, New York.
Clin Lab Med. 1993 Mar;13(1):183-207.
Methodologic aspects including causes of factitious hyperphosphatemia and hypophosphatemia are summarized. The differential diagnosis of hyperphosphatemia is reviewed under its three broad causes: decreased glomerular filtration rate, increased exogenous or endogenous phosphate load, and increased renal tubular phosphate reabsorption. The differential diagnosis of hypophosphatemia is reviewed under its three broad causes: inadequate gastrointestinal input, excess phosphate losses, and transcellular shifts. The consequences of hyperphosphatemia and hypophosphatemia are outlined with a focus on pathophysiologic and clinicochemical sequelae. A laboratory perspective is emphasized in outlining management strategies.
总结了包括假性高磷血症和低磷血症病因在内的方法学方面。高磷血症的鉴别诊断根据其三大病因进行综述：肾小球滤过率降低、外源性或内源性磷酸盐负荷增加以及肾小管磷酸盐重吸收增加。低磷血症的鉴别诊断根据其三大病因进行综述：胃肠道摄入不足、磷酸盐过度丢失和跨细胞转移。概述了高磷血症和低磷血症的后果，重点是病理生理和临床化学后遗症。在概述管理策略时强调了实验室视角。
