Coulombe R A
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-4620.
J Dairy Sci. 1993 Mar;76(3):880-91. doi: 10.3168/jds.S0022-0302(93)77414-7.
Mycotoxins are ubiquitous, mold-produced toxins that contaminate a wide variety of foods and feeds. Ingestion of mycotoxins cause a range of toxic responses, from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin, aflatoxin B1, is a presumed human hepatocarcinogen. As part of a comprehensive effort to curtail the adverse health effects posed by mycotoxins, substantial research has been conducted to determine the mechanism of action of mycotoxins in animals. This review presents some of the current knowledge on the biological action of four diverse classes of mycotoxins--aflatoxin B1, tricothecenes, zearalenone, and fumonisin B1--with particular emphasis on mechanisms of action.
霉菌毒素无处不在，是由霉菌产生的毒素，可污染各种各样的食品和饲料。摄入霉菌毒素会引发一系列毒性反应，从急性毒性到长期或慢性健康问题。一些霉菌毒素已导致人类中毒事件的爆发，并且至少有一种霉菌毒素——黄曲霉毒素B1——被认为是人类肝癌致癌物。作为减少霉菌毒素对健康造成不良影响的全面努力的一部分，已经开展了大量研究以确定霉菌毒素在动物体内的作用机制。本综述介绍了目前关于四类不同霉菌毒素——黄曲霉毒素B1、单端孢霉烯族毒素、玉米赤霉烯酮和伏马菌素B1——生物学作用的一些知识，尤其着重于作用机制。
