Jungers P, Ganeval D, Kleinknecht D
Nouv Presse Med. 1977 Mar 19;6(11):923-6.
Reversible acute renal failure was observed in 13 patients after combined antibiotic therapy using gentamicin. High and prolonged doses were used in 7 patients whose initial renal function was normal, while 6 other patients with preceding chronic renal insufficiency received usual doses of gentamicin. Precipitating factors were: increasing age, previous renal impairment, and combined use of other antibiotics, mainly cefalotin (8 patients). The nephrotoxicity of gentamicin is poor but well established, and may be prevented by checking the initial renal function, adjusting the dosage subsequently, and monitoring the renal function and gentamicin serum levels during therapy.
在13例使用庆大霉素联合抗生素治疗的患者中观察到可逆性急性肾衰竭。7例初始肾功能正常的患者使用了高剂量且持续时间长的庆大霉素，而另外6例先前患有慢性肾功能不全的患者接受了常规剂量的庆大霉素。诱发因素包括：年龄增长、既往肾损害以及其他抗生素（主要是头孢噻吩，8例）的联合使用。庆大霉素的肾毒性虽不常见但已明确，可通过检查初始肾功能、随后调整剂量以及在治疗期间监测肾功能和庆大霉素血清水平来预防。
