三环类抗抑郁药对缢蛏卵母细胞中5-羟色胺诱导的钙摄取的调节作用。

Regulation of serotonin-induced calcium uptake in Spisula oocytes by tricyclic antidepressants.

作者信息

Juneja R, Ueno H, Segal S J, Koide S S

机构信息

Center for Biomedical Research, Population Council, New York, NY 10021.

出版信息

Neurosci Lett. 1993 Mar 5;151(1):101-3. doi: 10.1016/0304-3940(93)90056-q.

DOI:10.1016/0304-3940(93)90056-q

PMID:8469428

Abstract

The effect of tricyclic antidepressants on 5-hydroxytryptamine (serotonin or 5-HT)-induced maturation and Ca2+ uptake in Spisula oocytes was determined. The drugs at a concentration of 20 microM completely blocked germinal vesicle breakdown and 45Ca2+ uptake by Spisula oocytes. The order of effectiveness of the antidepressants were imipramine > desipramine > clomipramine. The present findings suggest that the action of tricyclic antidepressants is to regulate Ca2+ uptake into 5-HT-responsive cells.

摘要

研究了三环类抗抑郁药对缢蛏卵母细胞中5-羟色胺（血清素或5-HT）诱导的成熟和Ca2+摄取的影响。浓度为20微摩尔的这些药物完全阻断了缢蛏卵母细胞的生发泡破裂和45Ca2+摄取。抗抑郁药的有效性顺序为丙咪嗪>地昔帕明>氯米帕明。目前的研究结果表明，三环类抗抑郁药的作用是调节Ca2+进入5-HT反应性细胞的摄取。