Schneider F, Lutun P, Tempé J D
Service de réanimation médicale, hôpital de Hautepierre, Strasbourg.
Rev Prat. 1993 Jan 1;43(1):41-5.
Sepsis syndrome occurs when an acute infection results in an host generalized inflammatory response including cytokines production. Death is a frequent and unpredictable sequel of this pathological condition. It may be due either to uncontrolled circulatory failure, or to multiple organ failure. With the advent of nitric oxide in the arena of the most potent vasodilatator agents, we now better understand the mechanisms of low vascular resistance during hyperkinetic septic shock. However a closer understanding of the mechanisms of multiple organ failure is actually required to improve survival rates during severe human sepsis.
当急性感染导致包括细胞因子产生在内的宿主全身性炎症反应时，就会发生脓毒症综合征。死亡是这种病理状况常见且不可预测的后果。它可能是由于无法控制的循环衰竭，或者是多器官衰竭。随着一氧化氮作为最有效的血管扩张剂之一进入人们的视野，我们现在对高动力型感染性休克期间低血管阻力的机制有了更好的理解。然而，为了提高严重人类脓毒症患者的生存率，实际上需要更深入地了解多器官衰竭的机制。
