Noguchi M, Mizukami Y, Michigishi T, Koyasaki N, Ohta N, Miyazaki I
Operation Center, Kanazawa University Hospital, Japan.
Int Surg. 1993 Jan-Mar;78(1):10-5.
We re-examined 239 patients with differentiated thyroid carcinoma (222 with papillary carcinoma and 17 with follicular carcinoma) especially for the clinico-pathologic entity of poorly differentiated carcinoma, and made univariate and multivariate analyses of the results to evaluate whether it would be of value in estimating the prognosis in thyroid cancer patients. In the univariate study, no significant difference was found in either survival and disease-free survival between papillary and follicular carcinomas, but between well differentiated and poorly differentiated carcinomas. In the multivariate study, however, the presence of poorly differentiated carcinoma did not appear to be an unfavorable prognostic factor. The sex, tumor size, and presence of distant metastases or grossly malignant residue in the neck after operation were, on the other hand, confirmed by the analyses to be important prognostic factors. We concluded that histologic subclassification may be less useful in estimating the prognosis in patients with differentiated thyroid carcinoma than other factors such as sex and the extent of the tumor.
我们对239例分化型甲状腺癌患者（222例乳头状癌和17例滤泡状癌）进行了重新检查，特别关注低分化癌的临床病理特征，并对结果进行单因素和多因素分析，以评估其对甲状腺癌患者预后评估是否有价值。在单因素研究中，乳头状癌和滤泡状癌在生存率和无病生存率方面均未发现显著差异，但高分化癌和低分化癌之间存在差异。然而，在多因素研究中，低分化癌的存在似乎并不是一个不利的预后因素。另一方面，分析证实性别、肿瘤大小、远处转移的存在或术后颈部肉眼可见的恶性残留是重要的预后因素。我们得出结论，与性别和肿瘤范围等其他因素相比，组织学亚分类在评估分化型甲状腺癌患者的预后方面可能用处较小。
Zotero 插件