Davies H D, Sakuls P, Keystone J S
Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada.
Arch Dermatol. 1993 May;129(5):588-91. doi: 10.1001/archderm.129.5.588.
Cutaneous larva migrans is an infection with a larval nematode, most frequently by dog or cat hookworms. It has a characteristic presentation that is easily recognizable. We reviewed the charts of 60 patients with cutaneous larva migrans who presented to the Tropical Disease Unit, Toronto (Ontario) Hospital, during a 6-year period.
Ninety-five percent of the patients were Canadians who had recently returned from the tropics or subtropics, notably the Caribbean. Almost all patients had a linear or serpiginous, very pruritic larval track. Topical thiabendazole was efficacious in 52 (98%) of 53 patients treated. Albendazole cured six (88%) of seven patients treated. Because of adverse effects, oral thiabendazole and liquid nitrogen were not utilized.
We conclude that topical thiabendazole and oral albendazole are very effective and safe modalities for the treatment of cutaneous larva migrans.
皮肤幼虫移行症是由幼虫线虫感染引起的疾病，最常见的是由犬或猫钩虫感染所致。其具有易于识别的特征性表现。我们回顾了60例皮肤幼虫移行症患者的病历，这些患者在6年期间就诊于多伦多（安大略省）医院热带病科。
95%的患者为加拿大人，他们近期从热带或亚热带地区归来，尤其是加勒比地区。几乎所有患者都有一条线状或匐行性、瘙痒剧烈的幼虫移行轨迹。53例接受治疗的患者中，52例（98%）使用局部噻苯达唑治疗有效。7例接受治疗的患者中，6例（88%）使用阿苯达唑治愈。由于不良反应，未使用口服噻苯达唑和液氮。
我们得出结论，局部噻苯达唑和口服阿苯达唑是治疗皮肤幼虫移行症非常有效且安全的方法。
