Shakhanbeh J, Lynn B
Department of Physiology, University College London, UK.
Brain Res. 1993 Apr 2;607(1-2):314-8. doi: 10.1016/0006-8993(93)91522-t.
The effect of morphine was examined under identical conditions on (a) antidromic vasodilatation, an 'efferent' function of C-nociceptors in the skin, and (b) afferent responses to heat and pressure of C-polymodal nociceptors. Morphine caused a large, naloxone-reversible, fall in peak antidromic vasodilatation (ADV). However it caused no significant change in heat or mechanical excitability of C-polymodal nociceptors in normal or mildly inflamed skin. The mechanisms by which morphine might affect efferent, but not afferent, functions of C-nociceptors are discussed.
在相同条件下，研究了吗啡对以下两方面的影响：(a) 逆向血管舒张，这是皮肤中C类伤害感受器的一种“传出”功能；(b) C类多模式伤害感受器对热和压力的传入反应。吗啡导致逆向血管舒张峰值大幅下降，且可被纳洛酮逆转。然而，在正常或轻度炎症皮肤中，吗啡对C类多模式伤害感受器的热或机械兴奋性没有显著影响。文中讨论了吗啡可能影响C类伤害感受器传出功能而非传入功能的机制。
