Turner S, Marosszeky B, Timms I, Boyages J
Department of Radiation Oncology, Westmead Hospital, NSW, Australia.
Int J Radiat Oncol Biol Phys. 1993 Apr 30;26(1):141-6. doi: 10.1016/0360-3016(93)90185-x.
To determine the influence of treatment on ambulancy, pain control and functional outcome of patients with Malignant Spinal Cord Compression.
One hundred and thirty-seven patients with Malignant Spinal Cord Compression presenting or referred to the Department of Radiation Oncology, Westmead Hospital between August 1, 1989 and August 1, 1990 were studied prospectively. Patients were treated with palliative radiation therapy alone, surgery followed by radiotherapy or surgery alone. Two patients were not treated. Post-treatment outcome was assessed in terms of ambulatory status, improvement in pain and functional independence using the Functional Independence Measure.
Thirteen of 16 patients (81%) who were ambulant pre-treatment remained ambulant after treatment. Two of 16 patients (16.5%) who were non-ambulant pre-treatment became ambulant following treatment. Pain improved following treatment in 22 of 30 patients (73%). This benefit was seen equally for ambulant and non-ambulant patients. A high level of functional independence was maintained in patients who remained ambulant.
We conclude that prompt treatment of patients with Malignant Spinal Cord Compression while still able to walk is effective in maintaining ambulancy and functional independence, and that treatment improves pain in most patients.
确定治疗对恶性脊髓压迫症患者步行能力、疼痛控制及功能结局的影响。
前瞻性研究了1989年8月1日至1990年8月1日期间在韦斯特米德医院放射肿瘤学部门就诊或转诊的137例恶性脊髓压迫症患者。患者接受单纯姑息性放射治疗、手术加放疗或单纯手术治疗。2例患者未接受治疗。使用功能独立性测量法根据步行状态、疼痛改善情况及功能独立性对治疗后的结局进行评估。
16例治疗前可步行的患者中有13例(81%)治疗后仍可步行。16例治疗前不能步行的患者中有2例(16.5%)治疗后能够步行。30例患者中有22例(73%)治疗后疼痛得到改善。可步行和不能步行的患者均出现了这种改善。仍可步行的患者维持了较高水平的功能独立性。
我们得出结论,对于仍能行走的恶性脊髓压迫症患者,及时治疗在维持步行能力和功能独立性方面是有效的,并且治疗可改善大多数患者的疼痛。