Perkash I, Giroux J
Spinal Cord Injury Service, Department of Veterans Affairs, Palo Alto, California.
J Urol. 1993 May;149(5):1068-71. doi: 10.1016/s0022-5347(17)36298-5.
A followup study on nonhospitalized spinal cord injury patients using clean intermittent catheterization was conducted to evaluate long-term clean intermittent catheterization for any genitourinary complications, and to institute and evaluate prompt management. A total of 50 patients (36 paraplegics and 14 quadriplegics) was followed for 3 months to 6.5 years (average followup 22 months). All patients had a baseline urodynamic study and renal scan before they were discharged from the hospital. Patients with a reflex bladder and sustained, high intravesical pressures (greater than 40 cm. water) were placed on anticholinergic medication to lower voiding pressures and maintain continence. Those on clean intermittent catheterization and condom drainage were also given alpha-blockers to achieve low pressure voiding and to control autonomic dysreflexia. Of 50 patients 43 (86%) acquired a total of 364 events of significant bacteriuria (10(4) or more colony-forming units per ml.) at a rate of 13.63 infections per 1,000 patient-days on clean intermittent catheterization. Subclinical symptoms for urinary tract infection were noted in 22 of the 43 patients (51%), whereas clinical symptoms for urinary tract infection were recorded in 16 of 43 (37%). These symptoms included fever in 8 patients, chills in 3, hematuria in 3 and flank pain in 2. There were 31 genitourinary complications in 21 patients noted during periodic diagnostic evaluations, with 6 classified as upper tract. Of 50 patients 4 (8%) required rehospitalization for urological problems. One patient died of questionable sepsis. Transurethral sphincterotomy was performed in 15 of the 50 patients (30%) and transurethral prostatectomy was done in 1 for multiple reasons, for example high intravesical voiding pressures, difficult catheterization, repeated symptomatic urinary tract infections or per patient request to discontinue clean intermittent catheterization. Of 7 patients who were catheterized by others 4 elected to discontinue long-term clean intermittent catheterization after an average of 13 months. Overall, 33 patients (66%) discontinued clean intermittent catheterization and 17 are still being followed on a long-term basis. Clean intermittent catheterization is a successful long-term option to drain bladders in spinal cord injury patients who can perform catheterization independently.
对采用清洁间歇性导尿的非住院脊髓损伤患者进行了一项随访研究,以评估长期清洁间歇性导尿是否会引发任何泌尿生殖系统并发症,并制定和评估及时的处理措施。共有50例患者(36例截瘫患者和14例四肢瘫患者)接受了3个月至6.5年的随访(平均随访22个月)。所有患者在出院前均进行了基线尿动力学研究和肾脏扫描。对于膀胱反射亢进且膀胱内压力持续较高(大于40厘米水柱)的患者,给予抗胆碱能药物以降低排尿压力并保持尿失禁。对于采用清洁间歇性导尿和阴茎套引流的患者,还给予α受体阻滞剂以实现低压排尿并控制自主神经反射异常。50例患者中有43例(86%)在清洁间歇性导尿期间共发生364次显著菌尿事件(每毫升10⁴或更多菌落形成单位),发生率为每1000患者日13.63次感染。43例患者中有22例(51%)出现尿路感染的亚临床症状,而43例中有16例(37%)记录有尿路感染的临床症状。这些症状包括8例发热、3例寒战、3例血尿和2例胁腹疼痛。在定期诊断评估期间,21例患者出现了31次泌尿生殖系统并发症,其中6例归类为上尿路并发症。50例患者中有4例(8%)因泌尿系统问题需要再次住院。1例患者死于可疑的败血症。50例患者中有15例(30%)接受了经尿道括约肌切开术,1例因多种原因(如膀胱内排尿压力高、导尿困难、反复出现有症状的尿路感染或患者要求停止清洁间歇性导尿)接受了经尿道前列腺切除术。在由他人导尿的7例患者中,4例在平均13个月后选择停止长期清洁间歇性导尿。总体而言,33例患者(66%)停止了清洁间歇性导尿,17例仍在接受长期随访。清洁间歇性导尿对于能够独立进行导尿的脊髓损伤患者来说是一种成功的长期膀胱引流方法。