月经周期、孕期及绝经后女性阴道中的雌激素和孕激素受体

Oestrogen and progesterone receptors in the human vagina during the menstrual cycle, pregnancy and postmenopause.

作者信息

Pérez-López F R, Campo López C, Alós L, Juste G, Ibañez F, Martínez-Hernández H

机构信息

Department of Obstetrics and Gynaecology, University of Zaragoza Faculty of Medicine, Spain.

出版信息

Maturitas. 1993 Mar;16(2):139-44. doi: 10.1016/0378-5122(93)90058-p.

DOI:10.1016/0378-5122(93)90058-p

PMID:8483426

Abstract

Oestrogen receptor (ER) and progesterone receptor (PR) concentrations were measured by enzyme immunoassays in human vaginal tissues. There were no significant differences in either case between the follicular and luteal phases, or in ER concentrations between regularly cycling and postmenopausal women. ER levels were significantly lower in pregnant than in non-pregnant women. PR levels were significantly lower in both postmenopausal and pregnant women than in regularly cycling women. A positive correlation between ER and PR was found in pregnant women and there were correlations between ER and both oestradiol and prolactin in postmenopausal women. This is the first study to compare both ER and PR in the human vagina during the menstrual cycle, pregnancy and postmenopause.

摘要

采用酶免疫分析法测定人阴道组织中的雌激素受体（ER）和孕激素受体（PR）浓度。在卵泡期和黄体期，无论是ER还是PR浓度均无显著差异；在月经周期正常的女性和绝经后女性之间，ER浓度也无显著差异。孕妇的ER水平显著低于非孕妇。绝经后女性和孕妇的PR水平均显著低于月经周期正常的女性。孕妇的ER和PR之间呈正相关，绝经后女性的ER与雌二醇及催乳素均存在相关性。这是第一项在月经周期、孕期及绝经后对人阴道中的ER和PR进行比较的研究。