胆囊收缩素拮抗剂对胆囊收缩素和五肽胃泌素胃酸反应的不同影响。

Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin.

作者信息

Corwin R L, Smith G P

机构信息

Department of Psychiatry, Cornell University Medical College, NY.

出版信息

Peptides. 1993 Mar-Apr;14(2):253-7. doi: 10.1016/0196-9781(93)90038-i.

DOI:10.1016/0196-9781(93)90038-i

PMID:8483804

Abstract

The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, given alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.

摘要

在六只未麻醉的大鼠中评估了CCK受体亚型在肽刺激胃酸分泌中的作用。CCK刺激的胃酸分泌未被CCKB/胃泌素受体拮抗剂L-365,260阻断，单独给予或与L-365,260联合给予CCKA受体拮抗剂地伐西匹时，胃酸分泌显著增加。L-365,260而非地伐西匹阻断了五肽胃泌素刺激的胃酸分泌，并且当联合给予时，地伐西匹消除了L-365,260的作用。我们得出结论：1）五肽胃泌素通过胃泌素型受体刺激胃酸分泌，但CCK可能不是，2）尽管同时阻断了CCKB/胃泌素和CCKA受体，五肽胃泌素和CCK仍可刺激胃酸分泌。