Hartveit E, Heggelund P
Department of Neurophysiology, University of Oslo, Norway.
Vis Neurosci. 1993 Mar-Apr;10(2):325-39. doi: 10.1017/s0952523800003722.
This study examined the influence of the pontomesencephalic peribrachial region (PBR) on the visual response properties of cells in the dorsal lateral geniculate nucleus (LGN). The response of single cells to a stationary flashing light spot was recorded with accompanying electrical stimulation of the PBR. The major objectives were to compare the effects of PBR stimulation on lagged and nonlagged cells, to examine how the visual response pattern of lagged cells could be modified by PBR stimulation and to examine whether the physiological criteria used to classify lagged and nonlagged cells are applicable during increased PBR input to the LGN. During PBR stimulation, the visual response was enhanced to a similar degree for lagged and nonlagged cells and the latency to half-rise of the visual response was reduced, particularly for the lagged X cells. The latency to half-fall of the visual response of lagged cells was not changed by PBR stimulation. Accordingly, the division of LGN cells into lagged and nonlagged cells based on visual response latencies was maintained during PBR stimulation. The initial suppression that a visual stimulus evokes in lagged cells was resistant to the effects of PBR stimulation. For the lagged cells, the largest response increase occurred for the initial part of the visual response. For the nonlagged cells, the largest increase occurred for the tonic part of the response. The results support the hypothesis that the differences in temporal response properties between lagged and nonlagged cells belong to the basic distinctions between these cell classes.
本研究考察了脑桥中脑臂周区（PBR）对背侧外侧膝状体核（LGN）细胞视觉反应特性的影响。在对PBR进行电刺激的同时，记录单细胞对静止闪烁光斑的反应。主要目的是比较PBR刺激对滞后和非滞后细胞的影响，研究PBR刺激如何改变滞后细胞的视觉反应模式，并考察在增加PBR输入至LGN期间，用于分类滞后和非滞后细胞的生理学标准是否适用。在PBR刺激期间，滞后和非滞后细胞的视觉反应增强程度相似，视觉反应半上升潜伏期缩短，尤其是滞后的X细胞。PBR刺激未改变滞后细胞视觉反应半下降潜伏期。因此，在PBR刺激期间，基于视觉反应潜伏期将LGN细胞分为滞后和非滞后细胞的分类方式得以维持。视觉刺激在滞后细胞中引发的初始抑制对PBR刺激的影响具有抗性。对于滞后细胞，视觉反应初始部分的反应增加最大。对于非滞后细胞，反应的强直部分增加最大。这些结果支持了以下假设，即滞后和非滞后细胞在时间反应特性上的差异属于这些细胞类型之间的基本区别。
