Nishihira T, Takagi T, Mori S
Second Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Nutrition. 1993 Mar-Apr;9(2):146-52.
With a commercially available balanced 10% amino acid solution as control (I), imbalance solutions were prepared by the removal of valine (II), valine and leucine (III), valine and isoleucine (IV), and valine, leucine, and isoleucine (V). The solutions, in combination with total parenteral nutrition, were given to rats with AH-109A hepatoma for 7 consecutive days to evaluate antitumor activity. Although there were no significant differences in carcass weight after treatment among groups I-IV, a decrease was noted in group V. Tumor weights in groups II-V, relative to that in group I, were 39, 57, 43, and 44%, respectively. Antitumor activity was thus noted in all imbalance groups, although activity in group III was lower than that in group II. These results indicate that the concurrent depletion of leucine and/or isoleucine along with valine is undesirable because of lower antitumor activity and an adverse effect on host development. Leucine is thus suggested to play an important role in augmenting the activity of valine-depleted imbalance.
以市售的平衡型10%氨基酸溶液作为对照（I），通过去除缬氨酸（II）、缬氨酸和亮氨酸（III）、缬氨酸和异亮氨酸（IV）以及缬氨酸、亮氨酸和异亮氨酸（V）来制备不平衡溶液。将这些溶液与全胃肠外营养相结合，连续7天给予患有AH - 109A肝癌的大鼠，以评估其抗肿瘤活性。尽管在I - IV组治疗后的胴体重量上没有显著差异，但V组出现了下降。相对于I组，II - V组的肿瘤重量分别为39%、57%、43%和44%。因此，在所有不平衡组中均观察到了抗肿瘤活性，尽管III组的活性低于II组。这些结果表明，由于抗肿瘤活性较低且对宿主发育有不利影响，缬氨酸与亮氨酸和/或异亮氨酸同时缺失是不可取的。因此，提示亮氨酸在增强缬氨酸缺失的不平衡状态的活性中起重要作用。
