Krähe J, Roll C, Hanssler L, Bonzel K E
Zentrum für Kinder- und Jugendmedizin, Universität Essen.
Monatsschr Kinderheilkd. 1993 Apr;141(4):303-7.
A child with severe gastroenteritis developed acute rhabdomyolysis combined with acute renal failure. The pathophysiological mechanisms of this clinical syndrome are not completely understood. Rhabdomyolysis is mainly due to osmotic changes on both sides of the cell membrane. The preventive and therapeutic measures consist of adequate fluid substitution, correction of electrolyte and acid-base imbalances, administration of diuretics and alkalization of the urine. Dialysis treatment may be necessary. In this particular case renal failure resolved but the child died of other organ failure.
一名患有严重肠胃炎的儿童发生了急性横纹肌溶解症并伴有急性肾衰竭。这种临床综合征的病理生理机制尚未完全明确。横纹肌溶解主要是由于细胞膜两侧的渗透压变化所致。预防和治疗措施包括充分的液体补充、纠正电解质和酸碱失衡、使用利尿剂以及碱化尿液。可能需要进行透析治疗。在这个特殊病例中,肾衰竭得到缓解,但患儿死于其他器官衰竭。