Egawa M, Inoue S, Satoh S, Takamura Y, Nagai K, Nakagawa H
Third Department of Internal Medicine, Yokohama City University, Medical School, Japan.
Brain Res Bull. 1993;31(3-4):293-9. doi: 10.1016/0361-9230(93)90220-6.
In the dynamic phase, 3 weeks after surgery, food intake increased especially during the latter part of the light cycle in VMH-lesioned rats, and the difference between light and dark cycles disappeared. The rhythms of serum insulin, glucose, and triglyceride disappeared. Concentrations of glucose during the light cycle were lower than those of sham-operated rats, although concentrations of triglyceride and insulin were higher than those of sham-operated rats at all times. In the static phase, 12 weeks after surgery, the difference of food intake between light and dark cycle appeared in VMH-lesioned rats, but the loss of rhythmicity for serum glucose, insulin, and triglyceride remained. Concentrations of glucose except early light phase and concentrations of triglyceride and insulin at all times were higher than those of sham-operated rats. VMH lesions thus abolished circadian rhythmicity in serum insulin, glucose, and triglyceride for a long period; however, the disturbed rhythmicity of food intake was reversible.
在动态期，即手术后3周，VMH损伤大鼠的食物摄入量增加，尤其是在光照周期的后半段，光照和黑暗周期之间的差异消失。血清胰岛素、葡萄糖和甘油三酯的节律消失。光照周期期间的葡萄糖浓度低于假手术大鼠，尽管甘油三酯和胰岛素浓度在所有时间都高于假手术大鼠。在静态期，即手术后12周，VMH损伤大鼠的光照和黑暗周期之间的食物摄入量差异出现，但血清葡萄糖、胰岛素和甘油三酯的节律性丧失仍然存在。除早期光照阶段外的葡萄糖浓度以及所有时间的甘油三酯和胰岛素浓度均高于假手术大鼠。因此，VMH损伤长期消除了血清胰岛素、葡萄糖和甘油三酯的昼夜节律；然而，食物摄入的紊乱节律是可逆的。
