[环孢素治疗纯红细胞再生障碍性贫血可迅速改善贫血并提高CD4/8比值]

[Cyclosporin for pure red cell aplasia caused rapid improvement of anemia and increase of CD4/8 ratio].

作者信息

Kaito K, Masuoka H, Kobayashi M, Nishiwaki K, Shimada T, Yoshida M, Ochiai S, Katayama T, Sakai O

机构信息

Second Department of Internal Medicine, Kashiwa Hospital, Jikei University School of Medicine.

出版信息

Rinsho Ketsueki. 1993 Feb;34(2):159-64.

PMID:8492414

Abstract

Ciclosporine (CS) caused rapid improvement of anemia and increase of CD 4/8 ratio in two patients with pure red cell aplasia (PRCA). One case was a 45 year old female who were unresponsive to steroids, plasmapheresis and high dose cyclophosphamide, and another was a 61 years old man with diabetes mellitus (DM) without any treatment for PRCA. In both cases hemoglobin increased soon after the initiation of CS and CD 4/8 ratio also rose from 0.80 to 1.47 and 1.78 to 1.98, respectively. There was no side effects to interrupt the course of the therapy. CS seems to inhibit the production of cytokines such as IL-2 and IFN-gamma, and it damages the activated suppressor/cytotoxic T cells. CS is an effective drug for not only refractory cases but the first step therapy for the untreated patients.

摘要

环孢素（CS）使两名纯红细胞再生障碍性贫血（PRCA）患者的贫血迅速改善，CD4/8比值升高。一例为45岁女性，对类固醇、血浆置换和大剂量环磷酰胺无反应，另一例为61岁男性糖尿病（DM）患者，未接受任何PRCA治疗。在这两例中，开始使用CS后血红蛋白很快升高，CD4/8比值也分别从0.80升至1.47以及从1.78升至1.98。没有出现中断治疗过程的副作用。CS似乎抑制白细胞介素-2和干扰素-γ等细胞因子的产生，并损害活化的抑制性/细胞毒性T细胞。CS不仅是难治性病例的有效药物，也是未治疗患者的首选治疗药物。