Hariz M, Löfroth P O, Bergenheim T, Fagerlund M, Henriksson R
Neurokirurgiska kliniken, Norrlands Universitetssjukhus, Umeå.
Lakartidningen. 1993 May 5;90(18):1744, 1747-50.
Fifteen patients with brain tumours or arteriovenous malformations (AVMs) underwent hypofractionated stereotactic irradiation, 2-5 fractions being delivered using a linear accelerator and a non-invasive stereotactic frame. Results of the treatment of brain metastases were comparable with those reported for single fraction radiosurgery. With the AVMs, the rate of obliteration would seem to be slower than that after radiosurgery, perhaps because the irradiated volumes in our study were significantly larger than those treated with radiosurgery. An advantage of hypofractionated stereotactic irradiation is that larger brain lesions can be treated than is appropriate with radiosurgery.
15名患有脑肿瘤或动静脉畸形（AVM）的患者接受了大分割立体定向放射治疗，使用直线加速器和非侵入性立体定向框架进行2 - 5次分割照射。脑转移瘤的治疗结果与单次分割放射外科手术报道的结果相当。对于AVM，闭塞率似乎比放射外科手术后的要慢，可能是因为我们研究中的照射体积明显大于放射外科手术治疗的体积。大分割立体定向放射治疗的一个优点是可以治疗比放射外科手术更适合治疗的更大的脑病变。
