Bibby J M, Hukins D W
Department of Medical Biophysics, University of Manchester, U.K.
Scand J Urol Nephrol. 1993;27(1):63-5. doi: 10.3109/00365599309180415.
Encrusting deposits form on urinary catheters as a result of infection by bacteria which produce urease. Urease catalyses the hydrolysis of urea to produce ammonia, with the result that the pH of the urine increases and the deposits are precipitated. It has been suggested that acidification of urine may prevent this rise in pH and so prevent encrustation. Experiments were performed in vitro to determine whether acidification could be used to prevent the rise in pH when urease is present in urine. It was found that, in the presence of urease, the initial decrease in pH resulting from acidification was countered by further urea being converted into ammonia. Thus, although acidic washout solutions may dissolve encrusting deposits, acidification of urine is not a feasible method for preventing catheter encrustation.
由于产脲酶细菌感染，导尿管上会形成结痂沉积物。脲酶催化尿素水解产生氨，结果尿液的pH值升高，沉积物沉淀出来。有人提出，尿液酸化可能会阻止pH值升高，从而防止结痂。进行了体外实验，以确定当尿液中存在脲酶时，酸化是否可用于防止pH值升高。结果发现，在脲酶存在的情况下，酸化导致的pH值最初下降会被进一步转化为氨的尿素所抵消。因此，尽管酸性冲洗液可能会溶解结痂沉积物，但尿液酸化并不是防止导尿管结痂的可行方法。
