人类红细胞载体介导的残余钾离子和钠离子转运

Carrier-mediated residual K+ and Na+ transport of human red blood cells.

作者信息

Denner K, Heinrich R, Bernhardt I

机构信息

Department of Biology, Humboldt University Berlin, Germany.

出版信息

J Membr Biol. 1993 Mar;132(2):137-45. doi: 10.1007/BF00239003.

DOI:10.1007/BF00239003

PMID:8496945

Abstract

Residual, i.e., (ouabain, bumetanide, and EGTA)-insensitive K+ and Na+ influxes as well as effluxes of human red blood cells are enhanced in isotonic solutions of low (NaCl + KCl) concentration using sucrose to maintain constant osmolarity. Various carrier models were tested to fit the experimental data of these fluxes simultaneously. The residual K+ and Na+ fluxes can be described on the basis of a carrier mechanism of competing substrates with modifier sites.

摘要

残余的，即（哇巴因、布美他尼和乙二醇双四乙酸）不敏感的钾离子和钠离子流入以及人类红细胞的流出，在使用蔗糖维持恒定渗透压的低（氯化钠 + 氯化钾）浓度等渗溶液中会增强。测试了各种载体模型以同时拟合这些通量的实验数据。残余的钾离子和钠离子通量可以基于具有修饰位点的竞争性底物的载体机制来描述。