急性淋巴细胞白血病中的t(8;14)(q11;q32)：两例病例描述

t(8;14)(q11;q32) in acute lymphoid leukemia: description of two cases.

作者信息

Testoni N, Zaccaria A, Martinelli G, Pelliconi S, Buzzi M, Farabegoli P, Panzica G, Tura S

机构信息

Centro di Genetica e Citogenetica Oncologica, Istituto di Ematologia L. e A. Seràgnoli, Università degli Studi di Bologna, Italy.

出版信息

Cancer Genet Cytogenet. 1993 May;67(1):55-8. doi: 10.1016/0165-4608(93)90044-m.

DOI:10.1016/0165-4608(93)90044-m

PMID:8504400

Abstract

An 8;14 chromosome translocation with breakpoints at q11 and q32, respectively, is described as the sole abnormality in bone marrow cells of two adult patients with common acute lymphoblastic leukemia (ALL). The Southern blot analysis revealed a rearrangement after BamHI and HindIII digestion and hybridization with a JH probe, thus demonstrating the involvement of the gene coding for the heavy chains of the immunoglobulins (IgH). Therefore, a pathogenetic mechanism similar to that observed in Burkitt's lymphoma and its variants, or in other lymphomas with t(11;14) or t(14;18), may be hypothesized. In all these cases IgH is juxtaposed to an oncogene (c-MYC, BCL-1, and BCL-2, respectively). A similar structure, with oncogene type potential, could be present on 8q11. The patients underwent a complete remission after induction therapy.

摘要

在两名成年普通急性淋巴细胞白血病（ALL）患者的骨髓细胞中，发现了一种8号与14号染色体易位，其断点分别位于q11和q32，这是唯一的异常情况。Southern印迹分析显示，在用BamHI和HindIII消化并与JH探针杂交后出现了重排，从而证明编码免疫球蛋白重链（IgH）的基因受累。因此，可以推测其发病机制与在伯基特淋巴瘤及其变异型，或其他伴有t(11;14)或t(14;18)的淋巴瘤中观察到的机制相似。在所有这些病例中，IgH分别与一个癌基因（c-MYC、BCL-1和BCL-2）并列。8q11上可能存在具有癌基因类型潜能的类似结构。诱导治疗后，患者实现了完全缓解。