多功能钙调蛋白依赖性蛋白激酶

The multifunctional Ca2+/calmodulin-dependent protein kinases.

作者信息

Schulman H

机构信息

Department of Pharmacology, Stanford University School of Medicine, California 94305-5332.

出版信息

Curr Opin Cell Biol. 1993 Apr;5(2):247-53. doi: 10.1016/0955-0674(93)90111-3.

DOI:10.1016/0955-0674(93)90111-3

PMID:8507497

Abstract

Ca2+ mediates the effect of many hormones, neurotransmitters and growth factors on contractility and motility, carbohydrate metabolism, cell cycle, gene expression and neuronal plasticity. Multifunctional Ca2+/calmodulin-dependent (CaM) kinase, CaM kinase Ia, CaM kinase Ib and CaM kinase IV are four of the kinases that mediate Ca(2+)-signaling pathways. Recent studies have clarified our understanding of their structure, regulation and function.

摘要

钙离子介导许多激素、神经递质和生长因子对收缩性和运动性、碳水化合物代谢、细胞周期、基因表达及神经元可塑性的影响。多功能钙/钙调蛋白依赖性（CaM）激酶，即CaM激酶Ia、CaM激酶Ib和CaM激酶IV，是介导钙信号通路的四种激酶。最近的研究使我们对它们的结构、调节和功能有了更清晰的认识。