用聚合超氧化物歧化酶预防缺血再灌注损伤。
Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.
作者信息
Rocca M, Capelli S, Fini M, Maltarello M C, Veronese F M, Caliceti P, Giardino R
机构信息
Department of Experimental Surgery, Istituto di Ricerca Codivilla-Putti I.O.R., Bologna.
出版信息
Boll Soc Ital Biol Sper. 1995 May-Jun;71(5-6):125-32.
The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.
在43只Wistar大鼠的左后肢急性缺血实验模型中，测试了使用天然或修饰的（mPEG-SOD）超氧化物歧化酶预防缺血再灌注损伤的效果。与对照组（30%）相比，mPEG-SOD治疗组的存活肢率有显著差异（p = 0.004）（86.6%）。这种差异在临床和肌肉标本的透射电镜分析中均得到证实。
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