甲病毒的出芽

Budding of alphaviruses.

作者信息

Strauss J H, Strauss E G, Kuhn R J

机构信息

Divn of Biology, California Institute of Technology, Pasadena 91125, USA.

出版信息

Trends Microbiol. 1995 Sep;3(9):346-50. doi: 10.1016/s0966-842x(00)88973-8.

DOI:10.1016/s0966-842x(00)88973-8

PMID:8520887

Abstract

The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid. The structural studies complement biochemical and molecular genetic studies showing that a sequence-specific interaction between the cytoplasmic domains of the glycoproteins and the nucleocapsid drives budding.

摘要

甲病毒的二十面体结构以及病毒核衣壳的外壳已被解析到非常高的分辨率，揭示了糖蛋白之间相互作用形成三聚体刺突以及与核衣壳相互作用的细节。这些结构研究补充了生物化学和分子遗传学研究，表明糖蛋白的细胞质结构域与核衣壳之间的序列特异性相互作用驱动病毒出芽。