Phosphorylation-dependent complexes of p120 Ras-specific GTPase-activating protein with p62 and p190. - Suppr | 超能文献

Phosphorylation-dependent complexes of p120 Ras-specific GTPase-activating protein with p62 and p190.

作者信息

Ellis C, Measday V, Moran M F

机构信息

Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.

出版信息

Methods Enzymol. 1995;255:179-92. doi: 10.1016/s0076-6879(95)55022-4.

DOI:10.1016/s0076-6879(95)55022-4

Abstract

摘要

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Phosphorylation-dependent complexes of p120 Ras-specific GTPase-activating protein with p62 and p190.

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2

Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.在c-src过表达细胞中，p21ras-GTP水平升高以及DNA合成增强，同时GAP相关蛋白p190和p62的酪氨酰磷酸化增强。

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Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein.p120 Ras GTP酶激活蛋白的两个SH2结构域协同结合酪氨酸磷酸化的p190 Rho GTP酶激活蛋白。

J Biol Chem. 1995 Jul 28;270(30):17947-52. doi: 10.1074/jbc.270.30.17947.

4

Complex formation between the p21ras GTPase-activating protein and phosphoproteins p62 and p190 is independent of p21ras signalling.p21ras GTP酶激活蛋白与磷蛋白p62和p190之间的复合物形成独立于p21ras信号传导。

Oncogene. 1993 Oct;8(10):2773-80.

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Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation.p190 RhoGAP与p120 RasGAP相互作用的磷酸酪氨酸（p-Tyr）依赖性和非依赖性机制：p190的酪氨酸1105（c-Src的底物）是复合物形成的唯一p-Tyr介导因子。

Mol Cell Biol. 1998 Dec;18(12):7052-63. doi: 10.1128/MCB.18.12.7052.

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Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.在缺乏p120-Gap的细胞中，Ras调控异常且p190酪氨酸磷酸化水平降低。

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Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.B淋巴细胞抗原受体信号转导的靶点包括p21ras GTP酶激活蛋白（GAP）和两种GAP相关蛋白。

J Immunol. 1993 Jan 15;150(2):377-86.

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The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors.p190是一种与分子量为120,000的Ras GAP结合的肿瘤抑制蛋白，其GTP酶和Rho GAP结构域可独立作为抗Ras肿瘤抑制因子发挥作用。

Cancer Res. 1997 Jun 15;57(12):2478-84.

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Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells.人白血病细胞髓单核细胞分化过程中酪氨酸磷酸化的p190的变化及其与I型p120和II型p100 rasGAPs的关联。

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The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.GAP的N端区域调节细胞骨架结构和细胞黏附。

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