Brown R C, Hoskins J A, Glass L R
MRC Toxicology Unit, University of Leicester, U.K.
Ann Occup Hyg. 1995 Oct;39(5):705-13. doi: 10.1016/0003-4878(95)00011-3.
The well-known health effects following exposure to amphibole asbestos have led to some concern about the potential for other fibrous materials to cause similar diseases. This paper presents a summary of some of the inhalation experiments conducted with ceramic fibres in both rats and hamsters at the Research and Consulting Company, Geneva. One ceramic fibre (designated RCF1) was tested in rats at four exposure levels, this fibre was also tested in hamsters. Three other fibres were only tested in rats at the highest level--30 mg m-3. The increased incidence of tumours in these experiments has been contrasted with the negative results obtained with glass or mineral wools. However, there is evidence that the ceramic fibres were longer than the glass fibres and that long ceramic fibres were retained in lung tissue to a greater extent. This is sufficient to explain the results without recourse to explanations based on chemical differences between fibres.
接触闪石石棉后会产生众所周知的健康影响，这引发了人们对其他纤维材料是否有潜在可能导致类似疾病的一些担忧。本文总结了日内瓦研究与咨询公司在大鼠和仓鼠身上进行的一些陶瓷纤维吸入实验。一种陶瓷纤维（命名为RCF1）在大鼠身上进行了四个暴露水平的测试，这种纤维也在仓鼠身上进行了测试。另外三种纤维仅在大鼠身上进行了最高水平——30毫克/立方米的测试。这些实验中肿瘤发病率的增加与玻璃棉或矿棉所得到的阴性结果形成了对比。然而，有证据表明陶瓷纤维比玻璃纤维更长，并且长陶瓷纤维在肺组织中的留存程度更高。这足以解释实验结果，而无需借助基于纤维之间化学差异的解释。
