去甲丙咪嗪对交感肾上腺系统释放去甲肾上腺素和肾上腺素的不同作用。
Differential actions of desipramine on sympathoadrenal release of noradrenaline and adrenaline.
作者信息
Eisenhofer G, Friberg P, Goldstein D S, Esler M
机构信息
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1424, USA.
出版信息
Br J Clin Pharmacol. 1995 Sep;40(3):263-5. doi: 10.1111/j.1365-2125.1995.tb05782.x.
Abstract
Spillovers noradrenaline (NA) and adrenaline (A) into plasma were examined before and after i.v. administration of 0.3-0.5 mg kg-1 desipramine (DMI) in 19 normal volunteers. DMI decreased the total body spillover of NA by 20 +/- 4%, but increased that of A by 45 +/- 10%. The results indicate differential sympathoadrenal actions of DMI, characterized by inhibition of NA release from sympathetic nerves and stimulation of A secretion from the adrenals. These effects of DMI provide an explanation for some of the cardiovascular complications of tricyclic antidepressant therapy and may also help to explain how sympathoadrenal function is differentially regulated.
摘要
在19名正常志愿者静脉注射0.3 - 0.5 mg/kg去甲丙咪嗪（DMI）前后，检测了去甲肾上腺素（NA）和肾上腺素（A）向血浆中的溢出情况。DMI使NA的全身溢出减少了20±4%，但使A的全身溢出增加了45±10%。结果表明DMI对交感肾上腺系统有不同的作用，其特征是抑制交感神经释放NA并刺激肾上腺分泌A。DMI的这些作用为三环类抗抑郁药治疗的一些心血管并发症提供了解释，也可能有助于解释交感肾上腺功能是如何被不同调节的。
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