Besset A, Tafti M, Villemin E, Borderies P, Billiard M
Sleep and Waking Disorders Unit, Gui de Chauliac Hospital, Montpellier, France.
Drugs Exp Clin Res. 1995;21(4):161-9.
Effects of zolpidem, a short acting non benzodiazepine hypnotic, have been studied in eight female poor sleepers, aged 25 to 54 years, documented during two consecutive adaptation nights. Subjects were recorded according to a 22 day single blind study. Placebo was given orally at bedtime on nights 2-4, zolpidem on nights 5-20 and finally placebo on nights 21-22. Polygraphic recordings (conventional analysis) were performed on nights 1-6; 12, 13; 19-22. Parameters of sleep continuity, sleep architecture and cyclical structure of sleep were studied. Zolpidem 10 mg showed a hypnotic effect on poor sleepers. It reduced sleep latency, increased total sleep time and decreased the number of awakenings during all recorded nights. During the first post-drug night a rebound insomnia was observed in two subjects only. Zolpidem did not increase specifically stage 2 to the detriment of stages 3 and 4 but it restored them during the first nights of administration. Study of the rapid eye movements-non rapid eye movements (REM-NREM) sleep cycles structure showed that the increase of stages 3 and 4 occurred only during the first part of the night. Finally, zolpidem had no effect on REM sleep temporal distribution.
对8名年龄在25至54岁的女性睡眠不佳者进行了研究，探讨短效非苯二氮䓬类催眠药唑吡坦的作用，连续两个适应夜晚记录相关情况。根据一项为期22天的单盲研究对受试者进行记录。在第2至4晚睡前口服安慰剂，第5至20晚服用唑吡坦，最后在第21至22晚服用安慰剂。在第1至6晚、第12和13晚、第19至22晚进行多导睡眠图记录（常规分析）。研究了睡眠连续性、睡眠结构和睡眠周期性结构的参数。10毫克唑吡坦对睡眠不佳者显示出催眠作用。它缩短了入睡潜伏期，增加了总睡眠时间，并减少了所有记录夜晚的觉醒次数。仅在两名受试者的用药后第一晚观察到反弹性失眠。唑吡坦并没有特别增加2期睡眠而损害3期和4期睡眠，而是在用药的第一晚恢复了它们。对快速眼动-非快速眼动（REM-NREM）睡眠周期结构的研究表明，3期和4期睡眠的增加仅发生在夜间的第一部分。最后，唑吡坦对REM睡眠的时间分布没有影响。
