人类TYRP1和TYRP2基因座的染色体结构以及酪氨酸酶相关蛋白基因家族的比较。

Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.

作者信息

Sturm R A, O'Sullivan B J, Box N F, Smith A G, Smit S E, Puttick E R, Parsons P G, Dunn I S

机构信息

Centre for Molecular and Cellular Biology, University of Queensland, Australia.

出版信息

Genomics. 1995 Sep 1;29(1):24-34. doi: 10.1006/geno.1995.1211.

DOI:10.1006/geno.1995.1211

PMID:8530077

Abstract

The structures of the human tyrosinase-related protein genes TYRP1 and TYRP2 have been determined and compared with that of the tyrosinase gene (TYR). The TYRP1 protein is encoded in 7 exons spread over 24 kb of genomic DNA. Characterization of a 55-kb contig encompassing the human TYRP2 locus reveals that the protein coding region is divided into 8 exons. All three members of the TYRP gene family share a common C-terminal membrane spanning exon. Examination of the position of other intron junctions suggests that TYRP1 was derived from a TYR duplication and then was itself duplicated to give rise to the TYRP2 gene. The evidence also suggests that at least some of the introns within the TYR, TYRP1, and TYRP2 coding regions were gained after duplication and that intron slippage is unlikely to have occurred.

摘要

已确定人类酪氨酸酶相关蛋白基因TYRP1和TYRP2的结构，并与酪氨酸酶基因（TYR）的结构进行了比较。TYRP1蛋白由分布在24kb基因组DNA上的7个外显子编码。对包含人类TYRP2基因座的55kb重叠群的特征分析表明，蛋白质编码区分为8个外显子。TYRP基因家族的所有三个成员都共享一个共同的C末端跨膜外显子。对其他内含子连接位置的检查表明，TYRP1源自TYR的复制，然后自身复制产生了TYRP2基因。证据还表明，TYR、TYRP1和TYRP2编码区内的至少一些内含子是在复制后获得的，并且不太可能发生内含子滑动。