Sugaya T, Sakai H, Sugiyama T, Imai K
Department of Internal Medicine (Section 1), Sapporo Medical University.
Nihon Rinsho. 1995 Oct;53(10):2540-4.
In patients with Sjögren's syndrome (SJS), it has been found that chronic atrophic gastritis is often associated with low HCl secretion or achlorhydria. However, the role of autoimmune injuring mechanism in the pathogenesis of the atrophic gastritis in SJS is unclear. In recent studies, Helicobacter pylori (HP) infection is accepted as the major cause of chronic gastritis. In our studies, HP infection was present in the half of SJS patients with atrophic gastritis. We also determined HP specific IgG antibody levels by enzyme-linked immunosorbent assay (ELISA). In SJS patients with gastric inflammatory cell infiltration, the IgG levels were high. We determined gastric parietal cell antibody (PCA) levels by ELISA, using a recombinant fusion protein of the alpha subunit of gastric H+, K(+)-ATPase. Our observation suggests that atrophic gastritis in SJS is caused by HP infection associated with gastric mucosal injury due to PCA.
在干燥综合征（SJS）患者中，已发现慢性萎缩性胃炎常与低盐酸分泌或无盐酸分泌有关。然而，自身免疫损伤机制在SJS萎缩性胃炎发病机制中的作用尚不清楚。在最近的研究中，幽门螺杆菌（HP）感染被认为是慢性胃炎的主要原因。在我们的研究中，一半的SJS萎缩性胃炎患者存在HP感染。我们还通过酶联免疫吸附测定（ELISA）测定了HP特异性IgG抗体水平。在有胃炎性细胞浸润的SJS患者中，IgG水平较高。我们使用胃H⁺，K⁺-ATP酶α亚基的重组融合蛋白，通过ELISA测定了胃壁细胞抗体（PCA）水平。我们的观察结果表明，SJS中的萎缩性胃炎是由HP感染与PCA导致的胃黏膜损伤相关引起的。
