Sagawa A, Tanimura K, Shinohara M, Warabi T
Center for Rheumatic Diseases, Sapporo Yamanoue Hospital.
Nihon Rinsho. 1995 Oct;53(10):2563-7.
Neuro-psychiatric involvement in primary Sjögren's syndrome (PSJS) has been summarized according to the literature. Sjögren's syndrome is an autoimmune disorder with a predilection for multi-system involvement. Recently, disorders of the peripheral nervous system (PNS) and central nervous system (CNS) in PSJS, as well as, other organ involvement has been reported increasingly. However, CNS involvement, including the symptoms mimicking multiple sclerosis in PSJS is a controversial issue. There is discrepancy in the frequency of CNS involvement in PSJS among investigators. As for psychiatric manifestations in PSJS, descriptions have been made by many investigators. Depression and anxiety are the most common psychiatric manifestations in PSJS. About 10% of the patients with SJS have a neuropathy which tends to predilect for trigeminal nerve involvement. Further investigations elucidating the mechanisms of neuro-psychiatric involvement in PSJS is required.
根据文献总结了原发性干燥综合征（PSJS）中的神经精神受累情况。干燥综合征是一种易累及多系统的自身免疫性疾病。最近，PSJS中外周神经系统（PNS）和中枢神经系统（CNS）的疾病以及其他器官受累的报道越来越多。然而，PSJS中CNS受累，包括类似多发性硬化症的症状，是一个有争议的问题。研究者们对PSJS中CNS受累的频率存在差异。至于PSJS中的精神症状表现，许多研究者都有过描述。抑郁和焦虑是PSJS中最常见的精神症状表现。约10%的干燥综合征患者患有神经病变，倾向于累及三叉神经。需要进一步研究阐明PSJS中神经精神受累的机制。
