慢性乙醇处理及其戒断后大鼠脑内苯二氮䓬受体1型和2型的放射自显影研究
Autoradiographical study of types 1 and 2 of benzodiazepine receptors in rat brain after chronic ethanol treatment and its withdrawal.
作者信息
Negro M, Fernández-López A, Calvo P
机构信息
Department of Biochemistry and MOlecular Biology, University of León, Spain.
出版信息
Neuropharmacology. 1995 Sep;34(9):1177-82. doi: 10.1016/0028-3908(95)00064-d.
The effect of chronic ethanol treatment, and its withdrawal on benzodiazepine binding sites in rat brain is described in this autoradiographical study using the benzodiazepine agonist [3H]flunitrazepam. Several areas of the rat cerebral cortex, hippocampus, mesencephalon, cerebellum and lateral geniculate nucleus were studied in animals, chronically treated with ethanol, and 24 or 48 hr after ethanol withdrawal. The [3H]flunitrazepam binding and the relative percentages of binding to BZ1 and BZ2 sites, using zolpidem as a BZ1 site inhibitor, are described. The cerebellum and red nucleus, which only express BZ1 binding sites, appear to be areas significantly modified by ethanol and its withdrawal. In no other structure did ethanol modify [3H]flunitrazepam binding nor change the relative percentage of BZ1 and BZ2 sites.
在这项放射自显影研究中，使用苯二氮䓬激动剂[3H]氟硝西泮描述了慢性乙醇处理及其戒断对大鼠脑内苯二氮䓬结合位点的影响。在长期用乙醇处理的动物以及乙醇戒断24或48小时后，研究了大鼠大脑皮质、海马、中脑、小脑和外侧膝状体核的几个区域。描述了[3H]氟硝西泮结合情况以及使用唑吡坦作为BZ1位点抑制剂时与BZ1和BZ2位点结合的相对百分比。仅表达BZ1结合位点的小脑和红核似乎是受乙醇及其戒断显著影响的区域。在其他结构中，乙醇既未改变[3H]氟硝西泮结合情况，也未改变BZ1和BZ2位点的相对百分比。
Zotero 插件