Fujieda M, Yokoyama W, Oishi N, Okada T, Kurashige T, Hamada G
Department of Pediatrics, Kochi Medical School, Nanokoku-city, Japan.
Acta Paediatr Jpn. 1995 Oct;37(5):642-4. doi: 10.1111/j.1442-200x.1995.tb03394.x.
We describe a 15 year old boy with renal hypouricemia who developed acute renal failure after a school athletics meeting, accompanied by appendicitis. During acute renal failure, the highest level of uric acid was 5.0 mg/dL, creatinine 7.9 mg/dL and urea nitrogen 58.6 mg/dL. After recovery, the serum uric acid fell to 0.9 mg/dL and the fractional excretion of uric acid (FEuA) exceeded the normal range. The probenecid and pyrazinamide tests showed that the patient had a total defect of uric acid reabsorption. This case suggested that strenuous exercise could be responsible for acute renal failure in patients with renal hypouricemia.
我们描述了一名15岁患有肾性低尿酸血症的男孩，他在一次学校田径运动会后并发阑尾炎，继而发展为急性肾衰竭。急性肾衰竭期间，尿酸最高水平为5.0mg/dL，肌酐为7.9mg/dL，尿素氮为58.6mg/dL。恢复后，血清尿酸降至0.9mg/dL，尿酸分数排泄率（FEuA）超过正常范围。丙磺舒和吡嗪酰胺试验表明该患者存在尿酸重吸收完全缺陷。该病例提示剧烈运动可能是肾性低尿酸血症患者急性肾衰竭的原因。
