中药对左氧氟沙星药代动力学的影响。
Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin.
作者信息
Hasegawa T, Yamaki K, Muraoka I, Nadai M, Takagi K, Nabeshima T
机构信息
Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):2135-7. doi: 10.1128/AAC.39.9.2135.
Abstract
The effects of single coadministrations of one of three traditional Chinese medicines, Hotyu-ekki-to, Rikkunshi-to, and Juzen-taiho-to, on the pharmacokinetics of levofloxacin (LVFX) were investigated with eight healthy volunteers in an open, random crossover fashion. Subjects each received a single oral dose of LVFX (200 mg) alone and then with a single coadministration of each Chinese medicine. There were no significant differences in any pharmacokinetic parameters of LVFX between the groups. Also, no significant changes in the urinary recovery (> 80%) and renal clearance of LVFX were observed. These results indicate that the Chinese medicines tested have no significant effect on the rate and extent of bioavailability or renal excretion of LVFX.
摘要
采用开放、随机交叉试验设计，在8名健康志愿者中研究了三种中药（柴胡桂枝干姜汤、六君子汤和十全大补汤）之一单剂量合用对左氧氟沙星（LVFX）药代动力学的影响。受试者分别单独口服单剂量LVFX（200mg），然后再与每种中药单剂量合用。各用药组LVFX的任何药代动力学参数均无显著差异。此外，未观察到LVFX的尿回收率（>80%）和肾脏清除率有显著变化。这些结果表明，所测试的中药对LVFX的生物利用度速率和程度或肾脏排泄无显著影响。
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本文引用的文献
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