Intracerebroventricular administration of neuropeptide Y inhibits release of noradrenaline in the hypothalamic paraventricular nucleus caused by manual restraint in the rat through an opioid system.

Intracerebroventricular injection of 1.5 micrograms neuropeptide Y (NPY) had no effect on basal release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN), measured by intracerebral microdialysis in the rat. However, it blocked the increase in NA release caused by manual restraint but not that by tail-pinch, and the effect was blocked by naloxone (1.0 mg/kg body weight). Thus, NPY attenuates NA release in the PVN by a painless stressor, such as manual restraint, through an opioid system.