Yu A, Yang J, Pawlyk A C, Tejani-Butt S M
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Brain Res. 1995 Aug 7;688(1-2):209-12. doi: 10.1016/0006-8993(95)00539-3.
Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induce an increase in the turnover of 5-HTT mRNA without affecting protein levels at 3 days.
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