Bigelow D C, Swanson P B, Saunders J C
Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, USA.
Laryngoscope. 1996 Jan;106(1 Pt 1):71-6. doi: 10.1097/00005537-199601000-00014.
The tympanic membrane (TM) in adult rats was surgically exposed and laser interferometry was used to measure TM velocity at the umbo for frequencies between 1.0 and 40.0 kHz. Velocity measures were obtained for five conditions: TM intact, and four progressively larger holes cut into the posterior region of the membrane. Photomicrographs of each condition were used to calculate the percentage of pars tensa lost to the perforation. The relation between TM velocity and stimulus sound pressure level (SPL) was also examined for each of the conditions. The results revealed a systematic loss in low-frequency velocity as perforation size increased. These observations were consistent with clinical reports of low-frequency hearing loss in the perforated human TM. The rat appears to be a successful model for studying this form of conductive pathology.
对成年大鼠的鼓膜（TM）进行手术暴露，并使用激光干涉测量法测量在umbo处频率介于1.0至40.0 kHz之间的TM速度。针对五种情况获得了速度测量值：TM完整，以及在鼓膜后部区域切割出四个逐渐增大的孔。每种情况的显微照片用于计算紧张部因穿孔而损失的百分比。还针对每种情况检查了TM速度与刺激声压级（SPL）之间的关系。结果显示，随着穿孔尺寸的增加，低频速度出现系统性损失。这些观察结果与人类穿孔鼓膜低频听力损失的临床报告一致。大鼠似乎是研究这种传导性病理形式的成功模型。
