Merola B, Sofia M, Longobardi S, Fazio S, Micco A, Esposito V, Colao A, Biondi B, Lombardi G
Department of Clinical and Molecular Endocrinology and Oncology, Federico II University, Naples, Italy.
Eur J Endocrinol. 1995 Dec;133(6):680-5. doi: 10.1530/eje.0.1330680.
Little is known of the respiratory function in patients with growth hormone (GH) deficiency. The aim of the present study was to evaluate lung volumes and respiratory muscle strength in patients diagnosed as GH deficient in childhood. Ten patients diagnosed as GH deficient in childhood and ten healthy subjects entered the study. For each subject the evaluation of respiratory function followed the same standard approach, consisting of respiratory muscle strength assessment, recording of flow-volume curves, measurement of static lung volumes and lung diffusing capacity. Both maximal inspiratory and expiratory mouth pressures were decreased in GH deficiency. Vital capacity, N2 functional residual capacity and total lung capacity were significantly reduced when compared to healthy subjects. Conversely, the residual volume and diffusing lung capacity to CO did not show any significant change. No significant change of percentage forced expiratory volume in 1 s/forced vital capacity ratio was observed. The decrease of respiratory mouth pressures was not correlated to the decrease of lung volumes. In conclusion, the results of this study show that adult patients affected with childhood onset GH deficiency suffer from impairment of ventilatory function and a decrease of respiratory muscle pressures, probably due to reduction of respiratory muscle strength.
关于生长激素（GH）缺乏患者的呼吸功能，人们了解甚少。本研究的目的是评估童年期被诊断为GH缺乏的患者的肺容量和呼吸肌力量。十名童年期被诊断为GH缺乏的患者和十名健康受试者进入了研究。对于每个受试者，呼吸功能评估遵循相同的标准方法，包括呼吸肌力量评估、流量-容积曲线记录、静态肺容量测量和肺弥散能力测量。GH缺乏患者的最大吸气和呼气口腔压力均降低。与健康受试者相比，肺活量、氮功能残气量和肺总量显著降低。相反，残气量和一氧化碳肺弥散能力没有任何显著变化。观察到1秒用力呼气量/用力肺活量比值没有显著变化。呼吸口腔压力的降低与肺容量的降低无关。总之，本研究结果表明，童年期起病的GH缺乏成年患者存在通气功能损害和呼吸肌压力降低，可能是由于呼吸肌力量下降所致。
