Arita H, Ichikawa K, Sakamoto M
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Neurosci Lett. 1995 Sep 8;197(2):113-6. doi: 10.1016/0304-3940(95)11907-e.
Microinjection of serotonin and 5-hydroxytryptamine2 (5-HT2) agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in nucleus ambiguus caused excitation of posterior cricoarytenoid (PCA) muscles of the larynx in anesthetized, spontaneously breathing cats. Intravenous administration of 5-HT2 antagonist ketanserin produced complete block of excitatory effect of DOM injection. Electrical stimulation of nucleus raphe pallidus caused excitation of PCA activity, that was blocked by pretreatment of ketanserin. These results indicate that serotonergic cells in the raphe pallidus provide tonic drive to medullary PCA motoneurons through 5-HT2 receptors.
向麻醉状态下自主呼吸的猫的疑核内微量注射5-羟色胺和5-羟色胺2（5-HT2）激动剂1-（2,5-二甲氧基-4-甲基苯基）-2-氨基丙烷（DOM），可引起喉部环杓后肌（PCA）兴奋。静脉注射5-HT2拮抗剂酮色林可完全阻断DOM注射的兴奋作用。电刺激中缝苍白核可引起PCA活动兴奋，这一作用可被酮色林预处理所阻断。这些结果表明，中缝苍白核中的5-羟色胺能细胞通过5-HT2受体向延髓PCA运动神经元提供紧张性驱动。
