Fine B A, Piver M S, McAuley M, Driscoll D
Department of Gynecologic Oncology, Roswell Park, Cancer Institute, Buffalo, NY, USA.
Am J Clin Oncol. 1996 Feb;19(1):39-44. doi: 10.1097/00000421-199602000-00009.
The outcome of 55 patients with primary vaginal carcinoma treated with radiation therapy at Roswell Park Cancer Institute was retrospectively reviewed. Forty-four (80%) had a squamous cell carcinoma and 11 (20%) had an adenocarcinoma. The median age was 61 years and the median dose of radiation administered, external beam and brachytherapy, was 7,040 cGy. Fifteen percent of patients developed severe radiation-induced complications, and 36% developed recurrence of disease. The overall 5-year survival and 5-year disease-free survival for the entire group was 49 and 58%, respectively. Variables positively influencing survival included younger age, early stage, involvement of the upper vagina, total radiation dosage > 7,500 cGy, and the use of combination external beam and brachytherapy. However, only age acted as an independent prognostic factor affecting survival. The pelvis was the site of disease in the majority of patients who suffered recurrence.
对罗斯韦尔帕克癌症研究所接受放射治疗的55例原发性阴道癌患者的治疗结果进行了回顾性研究。其中44例（80%）为鳞状细胞癌，11例（20%）为腺癌。患者的中位年龄为61岁，放射治疗（外照射和近距离放疗）的中位剂量为7040厘戈瑞。15%的患者出现严重的放射诱导并发症，36%的患者出现疾病复发。整个队列的5年总生存率和5年无病生存率分别为49%和58%。对生存有积极影响的变量包括年龄较小、分期较早、阴道上段受累、总放射剂量>7500厘戈瑞以及采用外照射和近距离放疗联合治疗。然而，只有年龄是影响生存的独立预后因素。大多数复发患者的疾病部位在盆腔。
