遗传性铜代谢异常的长 Evans 肉桂色（LEC）大鼠 7 个脑区微量元素分布的年龄依赖性和区域特异性差异。

Age-dependent and region-specific differences in the distribution of trace elements in 7 brain regions of Long-Evans Cinnamon (LEC) rats with hereditary abnormal copper metabolism.

作者信息

Saito T, Itoh T, Fujimura M, Saito K

机构信息

Department of Hygiene and Preventive Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

Brain Res. 1995 Oct 16;695(2):240-4. doi: 10.1016/0006-8993(95)00819-c.

DOI:10.1016/0006-8993(95)00819-c

PMID:8556337

Abstract

Cu, Mn, Mo, Rb and Zn concentrations of 7 brain regions in LEC rats were determined before (4 and 10 weeks old) and after (20 weeks old) the onset of jaundice. Cu in the LEC rat brain was less concentrated in all regions at 4 weeks of age and in synaptosomal fractions at 10 weeks but, conversely, more concentrated in 3 regions at 20 weeks than in control rats. Furthermore, Mo and Rb in 6 regions at 10 weeks of age and Mn at 20 weeks were more concentrated in the LEC rat brain than in control rats. These results showed that abnormal distributions of trace elements exist in the LEC rat brain before the onset of jaundice.

摘要

测定了LEC大鼠黄疸发作前（4周龄和10周龄）及发作后（20周龄）7个脑区的铜、锰、钼、铷和锌浓度。LEC大鼠脑内的铜在4周龄时所有脑区以及10周龄时突触体组分中的浓度均较低，但相反，在20周龄时，3个脑区的铜浓度高于对照大鼠。此外，10周龄时6个脑区的钼和铷以及20周龄时的锰在LEC大鼠脑中的浓度高于对照大鼠。这些结果表明，在黄疸发作前，LEC大鼠脑内存在微量元素的异常分布。