Cook D N
Department of Pathology, University of North Carolina, Chapel Hill 27599-7525, USA.
J Leukoc Biol. 1996 Jan;59(1):61-6. doi: 10.1002/jlb.59.1.61.
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Here, the biologic properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis. However, the MIP-1 alpha null mice have a mice have a reduced inflammatory reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses. Agent that inhibit the action of MIP-1 alpha may therefore prove useful for controlling inflammation in these and other settings.
巨噬细胞炎性蛋白1α（MIP-1α）是趋化因子C-C亚家族的成员，趋化因子是一个由低分子量、可诱导蛋白组成的大家族，在体外具有多种促炎活性，包括白细胞趋化作用。MIP-1α是一种特别有趣的趋化因子，因为除了其促炎活性外，它在体外和体内均能抑制造血干细胞的增殖。在此，根据最近关于MIP-1α基因敲除纯合子小鼠的数据，对MIP-1α的生物学特性进行综述。MIP-1α基因敲除小鼠的外周血或骨髓细胞没有明显异常，这表明MIP-1α对于正常造血不是必需的。然而，MIP-1α基因敲除小鼠对流感病毒的炎症反应减弱，并且对柯萨奇病毒诱导的心肌炎具有抗性。这些数据表明，MIP-1α对于对这些病毒的正常炎症反应是必需的。因此，抑制MIP-1α作用的药物可能被证明对控制这些及其他情况下的炎症有用。
