Matsusaka N, Sakamoto H, Sato I, Shinagawa K, Kobayashi H, Nishimura Y
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Japan.
J Radiat Res. 1995 Sep;36(3):196-202. doi: 10.1269/jrr.36.196.
Whole-body retention and fetal uptake of 65Zn under a Zn-deficient diet were studied in pregnant mice in the late gestational stage after a single oral administration of 65Zn. Whole-body retentions were much greater in mice given a Zn-deficient diet than in those given a Zn-normal diet. Accordingly, the amount of 65Zn transmitted to the offspring in utero was greater in the Zn-deficient diet group. In another experiment, fetal uptake of 65Zn in dams on gestation day 17 was examined over a period of 24 hr after a single intravenous administration of 65Zn to the Zn-deficient and Zn-normal animals. There was no major difference in fetal uptake between the two groups, indicative that approximately a similar proportion of the 65Zn retained in the maternal body was transmitted to the in utero offspring in both groups.
在妊娠后期，对缺锌饮食的怀孕小鼠单次口服给予65Zn后，研究了其全身对65Zn的潴留以及胎儿对65Zn的摄取情况。给予缺锌饮食的小鼠全身潴留量比给予正常锌饮食的小鼠大得多。因此，缺锌饮食组中子宫内传递给后代的65Zn量更大。在另一项实验中，对缺锌和正常锌的动物单次静脉注射65Zn后，在24小时内检查了妊娠第17天母鼠胎儿对65Zn的摄取情况。两组之间胎儿摄取没有显著差异，这表明母体中潴留的65Zn传递到子宫内后代的比例在两组中大致相似。
