Benmakroha Y, Zhang S, Rolfe P
Department of Biomedical Engineering and Medical Physics, Keele University, North Staffordshire Hospital Trust, Stoke-on-Trent, Staffs, UK.
Med Biol Eng Comput. 1995 Nov;33(6):811-21. doi: 10.1007/BF02523013.
In recent years the importance and utilisation of invasive chemical sensors have increased, especially in respect to their function and behaviour in a biological environment. This review aims to highlight the development of various sensors and reflect on the problems which can occur when the sensors come into contact with blood. Thus their haemocompatibility is a key area of importance. A clear understanding of their interaction with plasma proteins at the point of interface is fundamental as this determines their ultimate capability to function safely and effectively. There is also an overview of various techniques that have been developed, together with a broad summary of inherent problems which may arise when aiming to improve the haemocompatibility of invasive sensors for in vivo applications.
近年来，侵入式化学传感器的重要性和应用率有所提高，尤其是在其于生物环境中的功能和行为方面。本综述旨在突出各类传感器的发展，并思考传感器与血液接触时可能出现的问题。因此，它们的血液相容性是一个关键的重要领域。清楚了解它们在界面处与血浆蛋白的相互作用至关重要，因为这决定了它们安全有效运行的最终能力。本文还概述了已开发的各种技术，以及在旨在提高用于体内应用的侵入式传感器的血液相容性时可能出现的固有问题的广泛总结。
