Koszyca B, Ellis D, Toogood I, Byard R W
Department of Histopathology, Women's and Children's Hospital, North Adelaide, Australia.
Mycoses. 1995 Jul-Aug;38(7-8):277-80. doi: 10.1111/j.1439-0507.1995.tb00407.x.
Pulmonary zygomycosis is an aggressive, often terminal infection that may be found in patients who are immunocompromised as a result of cytotoxic chemotherapy. Conventional treatment is by surgical debridement augmented with high-dose intravenous amphotericin B, but even with such treatment the course is usually fulminant with a high mortality rate. Recent work has suggested that the new antifungal triazole, fluconazole, may be of benefit in treating zygomycete infection. The case of a 15-year-old boy who developed pulmonary zygomycosis while on chemotherapy for acute lymphoblastic leukaemia, and who survived for 11 months with oral fluconazole therapy alone, is supportive of this proposal.
肺接合菌病是一种侵袭性的、常为终末期的感染，可在因细胞毒性化疗而免疫功能低下的患者中发现。传统治疗方法是手术清创并辅以大剂量静脉注射两性霉素B，但即便采用这种治疗方法，病程通常仍很迅猛，死亡率很高。最近的研究表明，新型抗真菌三唑类药物氟康唑可能有助于治疗接合菌感染。一名15岁男孩在接受急性淋巴细胞白血病化疗期间患上肺接合菌病，仅接受口服氟康唑治疗就存活了11个月，这一病例支持了这一观点。
