Castillo I, Bartolomé J, Ruiz-Moreno M, Sanchez V, Navas S, Carreño V
Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain.
Pediatr Res. 1995 Oct;38(4):618-20. doi: 10.1203/00006450-199510000-00024.
Hepatitis C virus (HCV) 1a, 1b, 2a, and 2b subtypes have been studied in 30 serum samples and in 20 paired liver biopsies from children with chronic hepatitis C. One serum sample was negative to the four HCV subtypes studied. HCV 1b was detected alone in 53.3% (16/30) of the serum samples; HCV 1a alone in 23.3% (7/30) and a mixed infection in 20% (6/30). In liver samples, HCV mixed infection was detected in a significantly higher proportion (50%: p < 0.05) than in serum, whereas HCV 1b was detected alone in 35% (7/20) and HCV 1a alone in the remaining 15% (3/20) of liver samples. These results suggest that serum HCV genotyping may not reflect the viral population infecting the liver of a given patient. Additional studies should be performed concerning the pathobiology of hepatitis C virus with relation to the subtypes detected in liver.
对30份血清样本以及来自慢性丙型肝炎患儿的20对肝脏活检组织进行了丙型肝炎病毒（HCV）1a、1b、2a和2b亚型的研究。在所研究的4种HCV亚型中，有1份血清样本呈阴性。在血清样本中，单独检测到HCV 1b的占53.3%（16/30）；单独检测到HCV 1a的占23.3%（7/30），混合感染占20%（6/30）。在肝脏样本中，检测到HCV混合感染的比例（50%：p<0.05）显著高于血清样本，而在肝脏样本中，单独检测到HCV 1b的占35%（7/20），其余15%（3/20）的肝脏样本单独检测到HCV 1a。这些结果表明，血清HCV基因分型可能无法反映感染特定患者肝脏的病毒群体。应针对丙型肝炎病毒与在肝脏中检测到的亚型相关的病理生物学开展更多研究。
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