Milliez P Y, Thomine E, Plot E, Tadié M, Elbaz J S
Chirurgie Plastique, Hôpital Charles-Nicolle, Rouen.
Ann Chir Plast Esthet. 1995 Aug;40(4):412-20.
This study concerned the evaluation of wound healing after extensive skin resections in 18 minipigs, sutured with: continuous intradermal Polyglactin 910 suture or Polyamide, an interrupted intradermal sutures using the same resorbable suture material. Three equivalent groups were studied: 0, 3 and 6 cm skin resections were studied after using a dynamometer to record the tension necessary to join the wound margins. Results were evaluated 1 month later by light and electron microscopy, and were statistically correlated by Pearson's test. The wound tension was correlated with skin resection (r = 0.97, p < 10-4). The scar width was exponentially correlated with tension (r = 0.70, p < 10-3); the fibrous and cellular appearances increased with the skin resection. The absence of any significant statistical results prevents any conclusion concerning the superiority of one suture material or suture technique, but the group with no resection led to homogenous results, regardless of the suture technique, or suture material used. 3 and 6 cm resection the groups led to unpredictable and various results. Granulous reactions were observed in 7 out of 12 cases with resorbable suture, and only 1 of the 8 cases with non resorbable suture, but these results are not significant.
本研究关注18只小型猪在进行大面积皮肤切除术后的伤口愈合情况，分别采用以下缝合方式：连续皮内聚乙醇酸910缝线或聚酰胺缝线，以及使用相同可吸收缝线材料的间断皮内缝合。研究了三个等效组：在使用测力计记录拉拢伤口边缘所需张力后，对0、3和6厘米的皮肤切除情况进行研究。1个月后通过光学显微镜和电子显微镜评估结果，并通过Pearson检验进行统计学关联。伤口张力与皮肤切除相关（r = 0.97，p < 10⁻⁴）。瘢痕宽度与张力呈指数相关（r = 0.70，p < 10⁻³）；纤维和细胞外观随皮肤切除增加。由于缺乏任何显著的统计结果，无法得出关于一种缝线材料或缝合技术优越性的任何结论，但未进行切除的组无论使用何种缝合技术或缝线材料，均产生了均匀的结果。3厘米和6厘米切除组导致了不可预测的多样结果。在12例使用可吸收缝线的病例中有7例观察到颗粒反应，而在8例使用不可吸收缝线的病例中只有1例观察到，但这些结果并不显著。
