Crow T J
University Department of Psychiatry, Warneford Hospital, Oxford, UK.
Schizophr Res. 1995 Oct;17(2):135-45. doi: 10.1016/0920-9964(95)00059-u.
The contention of this paper is that psychoses are not a collection of separate and unrelated diseases, but a set of diverse expressions of a single underlying entity. It will be argued that there is a basic homogeneity of pathogenesis, that there are not multiple predisposing genes but a single gene that is associated with significant diversity. Therefore the problem is a unitary one. The challenge is to identify the nature and function of the gene. It will be argued that the gene is that by which homo sapiens has separated from other primate species, and that the diversity arises from selective pressures which continue to act on this specifically human gene.
本文的论点是，精神病并非一系列相互独立、毫无关联的疾病，而是单一潜在实体的一组多样表现形式。本文将论证，发病机制存在基本的同质性，不存在多个易感基因，而是存在一个与显著多样性相关的单一基因。因此，问题是单一的。挑战在于确定该基因的性质和功能。本文将论证，该基因是智人区别于其他灵长类物种的基因，而多样性源于持续作用于这个特定人类基因的选择压力。
